Rosemary and its protective potencies against COVID-19 and other cytokine storm associated infections: A molecular review
نویسندگان
چکیده
BACKGROUND: Nowadays, medicinal plants have attracted great interest in treatment of human diseases. Rosemary is a well-known plant which has been widely used for different therapeutic purposes. METHODS: This narrative review using databases including PubMed, ISI, Scopus, ScienceDirect, Cochrane, and google scholar, the most authoritative articles were searched, screened, analyzed. RESULTS: natural antioxidant removes reactive oxygen species from tissues increases expression on Nrf2 gene. its metabolites reduce inflammation by inhibiting production pro-inflammatory cytokines, decreasing NF-?B, infiltration immune cells to inflamed sites, affecting gut microbiome. Besides, rosmarinic acid rosemary extract positive effects renin-angiotensin-system. affects respiratory system reducing oxidative stress, inflammation, muscle spasm, also through anti-fibrotic properties. Carnosic able penetrate blood-brain-barrier act against free radicals, ischemia neurodegeneration brain. Cardioprotective include correcting lipid profile, controlling blood pressure inhibition ACE, prevention atherosclerosis, reduction cardiac hypertrophy. CONCLUSIONS: Accordingly, supplementation potential protective COVID-19 other cytokine storm associated infections, conclusion that needs more evaluations next clinical trials.
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ژورنال
عنوان ژورنال: Mediterranean Journal of Nutrition and Metabolism
سال: 2021
ISSN: ['1973-7998', '1973-798X']
DOI: https://doi.org/10.3233/mnm-210013